There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to decrease afferent suffering transmission and make analgesia. Thus, medicine like clonidine that focus on alpha-2 receptors can influence the transmission of discomfort. Combining these heart medicines with clonidine https://erico369igb5.wikipresses.com/user