If a dad or mum from the proband is thought to contain the pathogenic variant recognized from the proband, the danger into the sibs of inheriting the pathogenic variant is 50%. As a result of lessened penetrance, sibs who inherit the pathogenic variant may or may not build aHUS (see https://watercooledchillers26936.amoblog.com/5-simple-techniques-for-air-handling-units-ahus-54231806