Chemotherapy was potentiated by E7449 and single agent experienced substantial antitumor activity in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, most likely by means of TNKS inhibition. Per this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and appreciably altered expression of Wnt https://cx-546110987.jiliblog.com/86832038/the-basic-principles-of-lumacaftor